The Digestive Health Institute is a network of highly trained doctors and surgeons who treat disorders of the gastrointestinal (GI) tract, as well as the liver, gallbladder and pancreas. As it becomes increasingly complex to treat digestive diseases and GI cancer, optimizing care relies more on the close collaboration of experts from across disciplines.

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Submissions from 2024

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Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity., Patricia J Rodriguez, Brianna M Goodwin Cartwright, Samuel Gratzl, Rajdeep Brar, Charlotte Baker, Tyler J Gluckman, and Nicholas L Stucky

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Histotripsy-A Novel and Intriguing Technique of Liver Ablation., Colin J Rog, Mohamed Alassas, and Evan Ong

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Developmental and functional differences between CD39+CD103+ DP CD8 T cells from normal colon and tumor in CRC patients, W Rosales, Thomas Duhen, and See full list of authors in comments

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Experiences and Impacts Associated with a Spanish Language Cooking and Gardening Pilot Program, Sarah E Roth, Benjamin Gronowski, and Roma Leiva

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ASPEN international survey on ethical competencies dealing with decision-making in the use of artificially administered nutrition and hydration and competency application in clinical practice., Denise Baird Schwartz, Sarah Sumner, Diana Cardenas, Theodoric Wong, Maria Giuseppina Annetta, Babak Goldman, Albert Barrocas, Sonia Echeverri, Eliza Mei Perez Francisco, and Gil Hardy

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Evaluation of Aluminum Exposure in Neonates Receiving Parenteral Nutrition, Emma Sedarski

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Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease., Ujala Sehar, Upasana Mukherjee, Hafiz Khan, Malcolm Brownell, Keya Malhotra, John Culberson, Rainier Vladlen Alvir, and P Hemachandra Reddy

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Socially vulnerable patients are more likely to fail outpatient management of symptomatic cholelithiasis., Udai S Sibia, John R Klune, Cristina B Feather, Deanna Rider, Douglas Hanes, and Richard Essner

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Early Experiences With Bundled Payments for Care Improvement for Major Bowel Surgery., Udai S Sibia, John R Klune, Said Saiolghalam, and Anton J Bilchik

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The Milan score: A novel manometric tool for a more efficient diagnosis of gastro-esophageal reflux disease., Stefano Siboni, Marco Sozzi, Ivan Kristo, Sara Boveri, Benjamin D Rogers, Nicola De Bortoli, Anthony Hobson, Brian E Louie, Yeong Yeh Lee, Salvatore Tolone, Elisa Marabotto, Pierfrancesco Visaggi, Jordan Haworth, Megan L Ivy, Garrett Greenan, Takahiro Masuda, Roberto Penagini, Benedetta Barcella, Marina Coletta, Dimitrios Theodorou, Tania Triantafyllou, Chiara Facchini, Vincent Tee, Luigi Bonavina, Lorenzo Cusmai, Sebastian F Schoppmann, Edoardo Savarino, Emanuele Asti, and C Prakash Gyawali

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Elucidating human gut microbiota interactions that robustly inhibit diverse Clostridioides difficile strains across different nutrient landscapes., Jordy Evan Sulaiman, Jaron Thompson, Yili Qian, Eugenio I Vivas, Christian Diener, Sean M Gibbons, Nasia Safdar, and Ophelia S Venturelli

Adoptive cell therapy targeting mutations in gastrointestinal cancers, Eric Tran

“A Pinch of Salt – A Podcast by ERA”, Katherine Tuttle

“Cases in Diabetes, Kidney, and Cardio-Renal-Metabolic Disease”, Katherine Tuttle

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“Effects of semaglutide with and without concomitant SGLT2 inhibitor use in participants with type 2 diabetes and chronic kidney disease in the FLOW trial.”, Katherine Tuttle

“FLOW: Semaglutide scores big in diabetic patients with CKD”, Katherine Tuttle

“Glycemic Management in Persons with Diabetes and CKD”, Katherine Tuttle

“Kidney Disease and Obesity”, Katherine Tuttle

“Miracle weight-loss drugs could halt kidney disease too”, Katherine Tuttle

National Geographic Interview feature article, Katherine Tuttle

“New study shows Ozempic lowers kidney disease”, Katherine Tuttle

“New use for Ozempic”, Katherine Tuttle

“Ozempic cuts risk in kidney disease”, Katherine Tuttle

“Ozempic cuts risk of chronic kidney disease complications, study finds””, Katherine Tuttle

“Ozempic keeps wowing: trial data show benefits for kidney disease”, Katherine Tuttle

“Ozempic reduces risk of serious illness and death in people with diabetes and kidney disease, study finds", Katherine Tuttle

“Semaglutide cuts kidney failure and death in diabetes”, Katherine Tuttle

“Semaglutide significantly improves chronic kidney disease”, Katherine Tuttle

“Transformation of CKD Care to Delivery Kidney Health”, Katherine Tuttle

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Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial., Katherine R Tuttle, Sibylle J Hauske, Maria Eugenia Canziani, Maria Luiza Caramori, David Cherney, Lisa Cronin, Hiddo J L Heerspink, Christian Hugo, Masaomi Nangaku, Ricardo Correa Rotter, Arnold Silva, Shimoli V Shah, Zhichao Sun, Dorothea Urbach, Dick de Zeeuw, Peter Rossing, and ASi in CKD group

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Anal Condyloma and Human Papillomavirus: Recognition, Treatment, and Prevention., Kenley R Unruh and Debra D Lai

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Evaluation of Piperacillin-Tazobactam Dosing and Clinical Outcomes in Obese Patients, Maria C. Vazquez, Shalyn Cox, and Larry J Pineda

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Impact of Prior Biologic or Janus Kinase Inhibitor Therapy on Efficacy and Safety of Etrasimod in the ELEVATE UC 52 and ELEVATE UC 12 Trials., Séverine Vermeire, Bruce E Sands, Laurent Peyrin-Biroulet, Geert R D'Haens, Julian Panés, Andres J Yarur, Douglas C Wolf, Timothy Ritter, Stefan Schreiber, John C Woolcott, Irene Modesto, Michael Keating, Kevin Shan, Joseph Wu, Michael Chiorean, Filip Baert, Marla C Dubinsky, Martina Goetsch, Silvio Danese, and Brian G Feagan

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Ambulatory Robotic Colectomy: Factors Affecting and Affected by Postoperative Opioid Use., Michael M Vu, Jace J Franko, Anna Buzadzhi, Beau Prey, Maksim Rusev, Marta M Lavery, and Laila Rashidi

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Machine learning to understand risks for severe COVID-19 outcomes: a retrospective cohort study of immune-mediated inflammatory diseases, immunomodulatory medications, and comorbidities in a large US health-care system., Qi Wei, Philip J Mease, Michael Chiorean, Lulu Iles-Shih, Wanessa F Matos, Andrew Baumgartner, Sevda Molani, Yeon Mi Hwang, Basazin Belhu, Alexandra Ralevski, and Jennifer Hadlock

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AGA Clinical Practice Update on Advances in Per-Oral Endoscopic Myotomy (POEM) and Remaining Questions-What We Have Learned in the Past Decade: Expert Review., Dennis Yang, Robert Bechara, Christy M Dunst, and Vani J A Konda

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Colorectal Cancer Detection via Metabolites and Machine Learning., Rachel Yang, Igor F Tsigelny, Santosh Kesari, and Valentina L Kouznetsova

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Achievement of clinical, endoscopic, and histologic outcomes in patients with ulcerative colitis treated with etrasimod, and association with fecal calprotectin and C-reactive protein: results from the Phase 2 OASIS trial., Andres J Yarur, Michael Chiorean, Julián Panés, Vipul Jairath, Jinkun Zhang, Christopher J Rabbat, William J Sandborn, Séverine Vermeire, and Laurent Peyrin-Biroulet

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Etrasimod as a Monotherapy or With Concomitant Use of Corticosteroids and/or Aminosalicylates: Results From the ELEVATE UC Clinical Program., Andres J Yarur, Michael V Chiorean, Jessica R Allegretti, Raymond K Cross, Christina Ha, Martina Goetsch, Aoibhinn McDonnell, Alexis B Dalam, Joseph Wu, David A Blanco, Arcangelo M Abbatemarco, and Julian Panés

Targeting TGBF in Rectal Cancer, Kim Young

Targeting TGFβ in Rectal Cancer, Kim Young

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Detection and Quantification of Drug-Protein Adducts in Human Liver., Alex Zelter, Michael Riffle, David D Shteynberg, Guo Zhong, Ellen B Riddle, Michael R Hoopmann, Daniel Jaschob, Robert L Moritz, Trisha N Davis, Michael J MacCoss, and Nina Isoherranen

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Oncologic outcomes following transanal total mesorectal excision: the United States experience., Makda Getachew Zewde, Daniel K Peyser, Allen T Yu, Antoinette Bonaccorso, Erin Moshier, Karim Alavi, Robert Goldstone, John H Marks, Justin A Maykel, Elisabeth C McLemore, Dana Sands, Scott R Steele, Steven D Wexner, Mark Whiteford, and Patricia Sylla

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Association between class III obesity and overall survival in previously untreated younger patients with acute myeloid leukemia enrolled on SWOG S1203., Michelle Y Zhang, Megan Othus, Kerry McMillen, Harry P Erba, Guillermo Garcia-Manero, John M Pagel, Mohamed L Sorror, and Mary-Elizabeth M Percival

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Sex dimorphism and tissue specificity of gene expression changes in aging mice., Dantong Zhu, Matt Arnold, Brady A Samuelson, Judy Z Wu, Amber Mueller, David A Sinclair, and Alice E Kane

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Landscape of tumoral ecosystem for enhanced anti-PD-1 immunotherapy by gut Akkermansia muciniphila., Zhuxian Zhu, Jianguo Huang, Yanling Zhang, Weiwei Hou, Fei Chen, Yin-Yuan Mo, and Ziqiang Zhang

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Optimization of a standardized letter of recommendation for faculty who wish to support candidates applying to surgical training programs., Clare Zipf-Sigler, Alisha L Nguyen, Amber Huang, Ryan De Leon, Shannon Helbling, Eliza B Littleton, and Anjali S Kumar

Submissions from 2023

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Early recapture of response with tofacitinib 10 mg twice daily in patients with ulcerative colitis in OCTAVE Open following dose reduction or treatment interruption in OCTAVE Sustain., Jessica R Allegretti, Krisztina B Gecse, Michael Chiorean, Marjorie Argollo, Xiang Guo, Nervin Lawendy, Chinyu Su, Rajiv Mundayat, Jerome Paulissen, Leonardo Salese, and Peter M Irving

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Gut microbiota analyses of inflammatory bowel diseases from a representative Saudi population., Raed M Alsulaiman, Abdulaziz A Al-Quorain, Fahad A Al-Muhanna, Stanley Piotrowski, Ezzeddin A Kurdi, Chittibabu Vatte, Ahmed A Alquorain, Noorah H Alfaraj, Abdulaziz M Alrezuk, Fred L Robinson, Alexa K Dowdell, Turki A Alamri, Lauren Hamilton, Hetal Lad, Hui Gao, Divya Gandla, Brendan J Keating, Ryan Meng, Brian D. Piening, and Amein K Al-Ali

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American Society for Gastrointestinal Endoscopy guideline on management of post-liver transplant biliary strictures: methodology and review of evidence., Stuart K Amateau, Divyanshoo R Kohli, Madhav Desai, Srinath Chinnakotla, M Edwyn Harrison, Jean M Chalhoub, Nayantara Coelho-Prabhu, Sherif E Elhanafi, Nauzer Forbes, Larissa L Fujii-Lau, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Sunil G Sheth, Nikhil R Thiruvengadam, Nirav C Thosani, Bashar J Qumseya, and ASGE Standards of Practice Committee Chair

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Identifying barriers to shared decision-making about bariatric surgery in two large health systems., David Arterburn, Leah Tuzzio, Jane Anau, Cara C Lewis, Neely Williams, Anita Courcoulas, Diana Stilwell, Ali Tavakkoli, Bestoun Ahmed, Margie Wilcox, Gary S Fischer, Kathleen Paul, Matt Handley, Anirban Gupta, and Kathleen McTigue

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Nutrition support teams: Institution, evolution, and innovation., Albert Barrocas, Denise Baird Schwartz, Bruce R Bistrian, Peggi Guenter, Charles Mueller, Ronni Chernoff, and Jeanette M Hasse

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Health-care expenditures are less for minimally invasive than open colectomy for colon cancer: A US commercial claims database analysis., Amir L Bastawrous, I-Fan Shih, Yanli Li, Marissa Khalil, Biruk Almaz, and Robert K Cleary

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Impact of Eating a Carbohydrate-Restricted Diet on Cortical Atrophy in a Cross-Section of Amyloid Positive Patients with Alzheimer's Disease: A Small Sample Study., Jennifer Bramen, Prabha Siddarth, Emily S Popa, Gavin T Kress, Molly Rapozo, John F Hodes, Aarthi Ganapathi, Colby B Slyapich, Ryan M. Glatt, Kyron P Pierce, Verna R Porter, Claudia L Wong, Mihae Kim, Richelin V Dye, Stella Panos, Tess Bookheimer, Tori Togashi, Spencer Loong, Cyrus A Raji, Susan Y Bookheimer, Jared C Roach, and David A Merrill

Results from an expanded phase 1 trial of botensilimab, a multifunctional anti-CTLA-4, plus balstilimab (anti-PD-1) for metastatic heavily pretreated microsatellite stable colorectal cancer, AJ Bullock, RE Sanborn, and See all authors in comments

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American Society for Gastrointestinal Endoscopy guideline on post-ERCP pancreatitis prevention strategies: methodology and review of evidence., James L Buxbaum, Martin Freeman, Stuart K Amateau, Jean M Chalhoub, Aneesa Chowdhury, Nayantara Coelho-Prabhu, Rishi Das, Madhav Desai, Sherif E Elhanafi, Nauzer Forbes, Larissa L Fujii-Lau, Divyanshoo R Kohli, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly H Ruan, Jonathan Sadik, Sunil G Sheth, Nikhil R Thiruvengadam, Nirav C Thosani, Selena Zhou, and Bashar J Qumseya

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American Society for Gastrointestinal Endoscopy guideline on post-ERCP pancreatitis prevention strategies: summary and recommendations., James L Buxbaum, Martin Freeman, Stuart K Amateau, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Sherif E Elhanafi, Nauzer Forbes, Larissa L Fujii-Lau, Divyanshoo R Kohli, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly H Ruan, Sunil G Sheth, Nikhil R Thiruvengadam, Nirav C Thosani, and Bashar J Qumseya

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Personalized Clostridioides difficile engraftment risk prediction and probiotic therapy assessment in the human gut, Alex Carr, Nitin S Baliga, Christian Diener, and Sean M Gibbons

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Direct Oral Anticoagulants and Warfarin Safety in Rural Patients with Obesity., Zachary R Caverley, Ross J Bindler, Pamela Soh, and Sherri Mendelson

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Impact of Food Environments on Obesity Rates: A State-Level Analysis., Elizabeth Cerceo, Elena Sharma, Anne Boguslavsky, and Jean-Sebastien Rachoin

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Liver Metastases and Immune Checkpoint Inhibitor Efficacy in Patients With Refractory Metastatic Colorectal Cancer: A Secondary Analysis of a Randomized Clinical Trial., Eric X Chen, Jonathan M Loree, Emma Titmuss, Derek J Jonker, Hagen F Kennecke, Scott Berry, Felix Couture, Chaudharry E Ahmad, John R Goffin, Petr Kavan, Mohammed Harb, Bruce Colwell, Setareh Samimi, Benoit Samson, Tahir Abbas, Nathalie Aucoin, Francine Aubin, Sheryl Koski, Alice C Wei, Dongsheng Tu, and Chris J O'Callaghan

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Modeling of Treatment Outcomes with Tofacitinib Maintenance Therapy in Patients with Ulcerative Colitis: A Post Hoc Analysis of Data from the OCTAVE Clinical Program., Michael Chiorean, Marco Daperno, Charlie W Lees, Gianluca Bonfanti, Dimitrios Soudis, Irene Modesto, J Jasper Deuring, and Roger A Edwards

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Consensus classification of pediatric hepatocellular tumors: A report from the Children's Hepatic tumors International Collaboration (CHIC)., Soo-Jin Cho, Sarangarajan Ranganathan, Rita Alaggio, Rudolf Maibach, Yukichi Tanaka, Takeshi Inoue, Ivo Leuschner, Ronald de Krijger, Christian Vokuhl, Mark Krailo, Marcio Malogolowkin, Rebecka Meyers, Piotr Czauderna, Eiso Hiyama, Marc Ansari, Bruce Morland, Angela Trobaugh-Lotrario, Allison F O'Neill, Arun Rangaswami, Beate Häberle, and Dolores López-Terrada

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Tirzepatide and potential use for metabolically healthy obesity., Sidar Copur, Cem Tanriover, Furkan Yavuz, Katherine R Tuttle, and Mehmet Kanbay

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Comparison of robotic versus laparoscopic right colectomy node retrieval in the obese population., Karleigh R Curfman, Jessica M Gowing, Ruben M Lesnick, James M Scanlan, Ulrik G Wallin, John A Griffin, and Laila Rashidi

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Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial., Michael I D'Angelica, Ryan J Ellis, Jason B Liu, Brian C Brajcich, Mithat Gönen, Vanessa M Thompson, Mark E Cohen, Susan K Seo, Emily C Zabor, Michele L Babicky, David J Bentrem, Stephen W Behrman, Kimberly A Bertens, Scott A Celinski, Carlos H F Chan, Mary Dillhoff, Matthew E B Dixon, Carlos Fernandez-Del Castillo, Sepideh Gholami, Michael G House, Paul J Karanicolas, Harish Lavu, Shishir K Maithel, John C McAuliffe, Mark J Ott, Bradley N Reames, Dominic E Sanford, Umut Sarpel, Courtney L Scaife, Pablo E Serrano, Travis Smith, Rebecca A Snyder, Mark S Talamonti, Sharon M Weber, Adam C Yopp, Henry A Pitt, and Clifford Y Ko

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Results from a phase 1a/1b study of botensilimab (BOT), a novel innate/adaptive immune activator, plus balstilimab (BAL; anti-PD-1 antibody) in metastatic heavily pretreated microsatellite stable colorectal cancer (MSS CRC)., Anthony B. El-Khoueiry, K A Margolin, Rachel E Sanborn, and See all authors in comments

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Pemphigus vulgaris presenting with epigastric pain., Marawan Elmassry, Jerapas Thongpiya, Pitchaporn Yingchoncharoen, Jali Garza, Matthew Soape, and Kanak Das

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American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations., Nauzer Forbes, Sherif E Elhanafi, Mohammad A Al-Haddad, Nirav C Thosani, Peter V Draganov, Mohamed O Othman, Eugene P Ceppa, Vivek Kaul, Michael M Feely, Ilyas Sahin, James L Buxbaum, Audrey H Calderwood, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Larissa L Fujii-Lau, Divyanshoo R Kohli, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Sunil G Sheth, Andrew C Storm, Nikhil R Thiruvengadam, and Bashar J Qumseya

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ASGE Guideline on the role of endoscopy in the diagnosis of malignancy in biliary strictures of undetermined etiology: Summary and Recommendations., Larissa L Fujii-Lau, Nirav C Thosani, Mohammad Al-Haddad, Jared Acoba, Curtis J Wray, Rodrick Zvavanjanja, Stuart K Amateau, James L Buxbaum, Audrey H Calderwood, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Sherif E Elhanafi, Douglas S Fishman, Nauzer Forbes, Laith H Jamil, Terry L Jue, Divyanshoo R Kohli, Richard S Kwon, Joanna K Law, Jeffrey K Lee, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Mandeep S Sawhney, Sunil G Sheth, Andrew Storm, Nikhil R Thiruvengadam, Bashar J Qumseya, and ASGE Standards of Practice Committee Chair (2020-2023)

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ASGE Guideline on role of endoscopy in the diagnosis of malignancy in biliary strictures of undetermined etiology: Methodology and Review of Evidence., Larissa L Fujii-Lau, Nirav C Thosani, Mohammad Al-Haddad, Jared Acoba, Curtis J Wray, Rodrick Zvavanjanja, Stuart K Amateau, James L Buxbaum, Sachin Wani, Audrey H Calderwood, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Sherif E Elhanafi, Douglas S Fishman, Nauzer Forbes, Laith H Jamil, Terry L Jue, Divyanshoo R Kohli, Richard S Kwon, Joanna K Law, Jeffrey K Lee, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Mandeep S Sawhney, Sunil G Sheth, Andrew Storm, Nikhil R Thiruvengadam, Bashar J Qumseya, and ASGE Standards of Practice Committee Chair (2020-2023)

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Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment., Satoru Furuhashi, Matias A Bustos, Shodai Mizuno, Suyeon Ryu, Yalda Naeini, Anton J Bilchik, and Dave SB Hoon

Temporal shift in heart failure diagnoses among hospitalized patients within a large US integrated health system, Tyler Gluckman, ST Chiu, J Remick, and See full list of authors in comments

363 Billion Reasons to Care: Reversing the Risking Tide of Cardiovascular Events, Tyler Gluckman and H Page

Hemodynamic Profile of Obesity in Cardiogenic Shock, ME Guglin, Jacob Abraham, and See full list of authors in comments

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Monitoring and Surveillance of Patients with Gastroenteropancreatic Neuroendocrine Tumors Undergoing Radioligand Therapy., Thorvardur R Halfdanarson, Nadine Mallak, Scott Paulson, Chandrikha Chandrasekharan, Mona Natwa, Ayse Tuba Kendi, and Hagen F Kennecke

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Biliary and pancreatic stents., Samuel Han; Jorge V Obando; Amit Bhatt; Juan Carlos Bucobo; Dennis Chen; Andrew P Copland; Koushik K Das; Mohit Girotra; Allon Kahn; Kumar Krishnan; Sonali S Sakaria; Monica Saumoy; Guru Trikudanathan; Arvind J Trindade; Julie Yang; Ryan J Law; ASGE Technology Committee Chair; David R Lichtenstein; and (previous Committee Chair, 2019-2021)

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Serum miRNA profiles are altered in patients with primary sclerosing cholangitis receiving high-dose ursodeoxycholic acid., Jessica T Hochberg, Aalam Sohal, Priya Handa, Bryan D Maliken, Take-Kyun Kim, Kai Wang, Eric Gochanour, Yu Li, J Bart Rose, James E Nelson, Keith D Lindor, Nicholas F LaRusso, and Kris V Kowdley

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A Diagnostic Conundrum - Small bowel obstruction from undiagnosed endometriosis following uterine perforation., Erina Horikawa, Carmen R Abbe, Brian E Staley, and Luay Ailabouni

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Generally-healthy individuals with aberrant bowel movement frequencies show enrichment for microbially-derived blood metabolites associated with impaired kidney function., James P Johnson, Christian Diener, Anne E Levine, Tomasz Wilmanski, David L Suskind, Alexandra Ralevski, Jennifer J Hadlock, Andrew T Magis, Leroy Hood, Noa Rappaport, and Sean M Gibbons

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Management of pediatric toxic ingestions in the emergency department., Mia Kanak, Stacy M Tarango, and Deborah R Liu

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The risk for chronic kidney disease in metabolically healthy obese patients: A systematic review and meta-analysis., Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah B Yildiz, Metehan Berkkan, Kathherine R Tuttle, and Carmine Zoccali

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Hormone Receptor-Positive Breast Cancer Sensitive to Pembrolizumab: Evidence of the Pathogenicity of the MLH1 Variant 1835del3., Henry G Kaplan, Jeffrey R Whiteaker, Brianna Nelson, Richard G Ivey, Travis D Lorentzen, Uliana Voytovich, Lei Zhao, David J Corwin, Robert Resta, and Amanda G Paulovich

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NCI Rectal-Anal Task Force consensus recommendations for design of clinical trials in rectal cancer., Hagen F Kennecke, Rebecca Auer, May Cho, N Arvind Dasari, Cynthia Davies-Venn, Cathy Eng, Jennifer Dorth, Julio Garcia-Aguilar, Manju George, Karyn A Goodman, Lillian Kreppel, Joshua E Meyer, Jose Monzon, Leonard Saltz, Deborah Schrag, J Joshua Smith, Jason A Zell, Prajnan Das, and National Cancer Institute Rectal-Anal Task Force

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A Novel Noninvasive Device and Method for Assessing Endothelial Function Is Associated With Measures of Obesity and Fitness., Kellen A Knowles, Kerry J Stewart, Pamela Ouyang, Kathy Magliato, Michael D Whitt, and Harry A Silber

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American Society for Gastrointestinal Endoscopy guideline on management of post-liver transplant biliary strictures: summary and recommendations., Divyanshoo R Kohli, Stuart K Amateau, Madhav Desai, Srinath Chinnakotla, M Edwyn Harrison, Jean M Chalhoub, Nayantara Coelho-Prabhu, Sherif E Elhanafi, Nauzer Forbes, Larissa L Fujii-Lau, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Sunil G Sheth, Nikhil R Thiruvengadam, Nirav C Thosani, Bashar J Qumseya, and ASGE Standards of Practice Committee Chair

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The Effect of Preoperative Carbohydrate Intake on Length of Stay and Postoperative Recovery Following Laparoscopic Living Donor Nephrectomy., Morgan Kuiper, Melanie Gillingham, Julie Martin, Daniella Gardner, and Sandra Van Calcar

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Incarcerated Prolapsed Sigmoid Intussusception Presenting as Rectal Prolapse Without a Lead Point., Debra Lai, Marta M Lavery, and Ulrik Wallin

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Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition., Su-Hyung Lee, Ela W Contreras Panta, David Gibbs, Yoonkyung Won, Jimin Min, Changqing Zhang, Joseph T Roland, Se-Hoon Hong, Yoojin Sohn, Evan Krystofiak, Bogun Jang, Lorenzo Ferri, Veena Sangwan, Jiannis Ragoussis, Sophie Camilleri-Broët, Joseph Caruso, Chira Chen-Tanyolac, Michael Strasser, Philippe Gascard, Thea D Tlsty, Sui Huang, Eunyoung Choi, and James R Goldenring

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Postvaccination Symptoms After a Fourth Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease., Yoo Jin Lee, Dalin Li, Angela Mujukian, Philip Debbas, Melissa Hampton, Emebet Mengesha, Susan Cheng, Joseph E Ebinger, Michael Chiorean, Donald Lum, Oriana M Damas, Jonathan Braun, Dermot P B McGovern, and Gil Y Melmed

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Growth phase estimation for abundant bacterial populations sampled longitudinally from human stool metagenomes., Joe J Lim, Christian Diener, James Wilson, Jacob J Valenzuela, Nitin S Baliga, and Sean M Gibbons

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Feasibility of circulating tumor DNA (ctDNA) to guide organ preservation in patients with node-negative rectal cancer undergoing neoadjuvant chemotherapy, excision, and observation in the phase II CCTG CO.28 trial, Jonathan M. Loree, Hagen F Kennecke, and See full list of authors in comments

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Clinical validation of contrast-enhanced ultrasound liver imaging reporting and data system in a prospective multinational study in North America and Europe., Andrej Lyshchik, Corinne E Wessner, Kristen Bradigan, John R Eisenbrey, Flemming Forsberg, Misung Yi, Scott W Keith, Yuko Kono, Stephanie R Wilson, Alexandra Medellin, Shuchi K Rodgers, Virginia Planz, Aya Kamaya, Lisa Finch, David Fetzer, Annalisa Berzigotti, Paul S Sidhu, and Fabio Piscaglia

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Evolution in the treatment of gastroesophageal reflux disease over the last century: from a crural-centered to a lower esophageal sphincter-centered approach and back., Emily M Mackay and Brian E Louie

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Obesity Modifies Clinical Outcomes of Right Ventricular Dysfunction., Janet I Ma, Emily K Zern, Juhi K Parekh, Ndidi Owunna, Nona Jiang, Dongyu Wang, Paula K Rambarat, Eugene Pomerantsev, Michael H Picard, and Jennifer E Ho

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A water-soluble alternative to simethicone for gastrointestinal endoscopy: Results of a clinical trial., Teri S Mallard, Sandra S Roswell, Evan P Sylvester, Cori L Ofstead, James M Scanlan, John J Brandabur, and Amarnath V Ramakrishnan

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Plasma phosphocreatine (PC) as a predictive biomarker for immune checkpoint inhibition in patients with refractory metastatic colorectal cancer (mCRC): Analysis of the CCTG CO.26 trial., Lucy Xiaolu Ma, Hagen F Kennecke, and See full list of authors in comments

Plasma arginine as a candidate predictive biomarker for response to immune checkpoint inhibition (ICI) in metastatic colorectal cancer (mCRC): Analysis of the CCTG CO.26 trial, LX Ma, H Kennecke, and See all authors in comments

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Disease-specific loss of microbial cross-feeding interactions in the human gut., Vanessa R Marcelino, Caitlin Welsh, Christian Diener, Emily L Gulliver, Emily L Rutten, Remy B Young, Edward M Giles, Sean M Gibbons, Chris Greening, and Samuel C Forster

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Disease-specific loss of microbial cross-feeding interactions in the human gut, Vanessa R. Marcelino, Caitlin Welsh, Christian Diener, Emily L. Gulliver, Emily L. Rutten, Remy B. Young, Edward M. Giles, Sean M Gibbons, Chris Greening, and Samuel C. Forster