Institute for Systems Biology (ISB) is a Providence-affiliated cross-disciplinary non-profit biomedical research organization based in Seattle. We focus on some of the most pressing issues in human health, including aging, brain health, cancer, COVID-19, the human microbiome, as well as many infectious diseases. ISB’s science is translational, and we champion sound scientific research that results in real-world clinical impacts. Learn more at isbscience.org, and see our published research papers here.

Follow

Submissions from 2017

PDF

Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast., Zhuo Wang, Samuel A Danziger, Benjamin D Heavner, Shuyi Ma, Jennifer J Smith, Song Li, Thurston Herricks, Evangelos Simeonidis, Nitin Baliga, John D Aitchison, and Nathan D Price

PDF

The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort., Kuo-Chen Wei, Chia-Yuan Chen, Li-Ying Feng, Wei-Tzu Huang, Chia-Hua Chen, Peng-Wei Hsu, Kai Wang, Leroy Hood, and Leslie Y Chen

PDF

sRNAnalyzer-a flexible and customizable small RNA sequencing data analysis pipeline., Xiaogang Wu, Taek-Kyun Kim, David Baxter, Kelsey Scherler, Aaron Gordon, Olivia Fong, Alton Etheridge, David J Galas, and Kai Wang

PDF

Extracting Intercellular Signaling Network of Cancer Tissues using Ligand-Receptor Expression Patterns from Whole-tumor and Single-cell Transcriptomes., Joseph X Zhou, Roberto Taramelli, Edoardo Pedrini, Theo Knijnenburg, and Sui Huang

PDF

Building ProteomeTools based on a complete synthetic human proteome., Daniel P Zolg, Mathias Wilhelm, Karsten Schnatbaum, Johannes Zerweck, Tobias Knaute, Bernard Delanghe, Derek J Bailey, Siegfried Gessulat, Hans-Christian Ehrlich, Maximilian Weininger, Peng Yu, Judith Schlegl, Karl Kramer, Tobias Schmidt, Ulrike Kusebauch, Eric W Deutsch, Ruedi Aebersold, Robert L Moritz, Holger Wenschuh, Thomas Moehring, Stephan Aiche, Andreas Huhmer, Ulf Reimer, and Bernhard Kuster

PDF

The Promise of Systems Biology Approaches for Revealing Host Pathogen Interactions in Malaria., Meghan Zuck, Laura S Austin, Samuel A Danziger, John D Aitchison, and Alexis Kaushansky

Submissions from 2016

PDF

An Open Data Format for Visualization and Analysis of Cross-Linked Mass Spectrometry Results., Michael R Hoopmann, Luis Mendoza, Eric W Deutsch, David Shteynberg, and Robert L Moritz

PDF

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy., Theo A Knijnenburg, Gunnar W Klau, Francesco Iorio, Mathew J Garnett, Ultan McDermott, Ilya Shmulevich, and Lodewyk F A Wessels

Link

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections., Martin McPhillie, Ying Zhou, Kamal El Bissati, Jitender Dubey, Hernan Lorenzi, Michael Capper, Amanda K Lukens, Mark Hickman, Stephen Muench, Shiv Kumar Verma, Christopher R Weber, Kelsey Wheeler, James Gordon, Justin Sanders, Hong Moulton, Kai Wang, Taek-Kyun Kim, Yuqing He, Tatiana Santos, Stuart Woods, Patty Lee, David Donkin, Eric Kim, Laura Fraczek, Joseph Lykins, Farida Esaa, Fatima Alibana-Clouser, Sarah Dovgin, Louis Weiss, Gael Brasseur, Dyann Wirth, Michael Kent, Leroy Hood, Brigitte Meunieur, Craig W Roberts, S Samar Hasnain, Svetlana V Antonyuk, Colin Fishwick, and Rima McLeod

PDF

Quantitative Proteomic Analysis of Stratum Corneum Dysfunction in Adult Chronic Atopic Dermatitis., Jason M Winget, Deborah Finlay, Kevin J Mills, Tom Huggins, Charles Bascom, Robert J Isfort, and Robert L Moritz